Estimated Regional White Matter Hyperintensity Burden, Resting State Functional Connectivity, and Cognitive Functions in Older Adults.

ABSTRACT:

Objective

White matter hyperintensities (WMH) are linked to deficits in cognitive functioning, including cognitive control and memory; however, the structural, and functional mechanisms are largely unknown. We investigated the relationship between estimated regional disruptions to white matter fiber tracts from WMH, resting state functional connectivity (RSFC), and cognitive functions in older adults.

Design

Cross-sectional study.

Setting

Community.

Participants

Fifty-eight cognitively-healthy older adults.

Measurements

Tasks of cognitive control and memory, structural MRI, and resting state fMRI. We estimated the disruption to white matter fiber tracts from WMH and its impact on gray matter regions in the cortical and subcortical frontoparietal network,

SUBMITTER: Jaywant A 

PROVIDER: S-EPMC8799753 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature