MRI Based Validation of Abdominal Adipose Tissue Measurements From DXA in Postmenopausal Women.

ABSTRACT:

Introduction

Visceral adipose tissue (VAT) is a hypothesized driver of chronic disease. Dual-energy X-ray absorptiometry (DXA) potentially offers a lower cost and more available alternative compared to gold-standard magnetic resonance imaging (MRI) for quantification of abdominal fat sub-compartments, VAT and subcutaneous adipose tissue (SAT). We sought to validate VAT and SAT area (cm²) from historical DXA scans against MRI.

Methodology

Participants (n = 69) from the Women's Health Initiative (WHI) completed a 3 T MRI scan and a whole body DXA scan (Hologic QDR2000 or QDR4500; 2004-2005). A subset of 43 participants were scanned on both DXA devices. DXA-derived VAT and SAT at the 4th lumbar vertebrae (5 cm wide) were analyzed using APEX software (v4.0, Hologic, I

SUBMITTER: Bea JW 

PROVIDER: S-EPMC8799761 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature