Comprehensive analysis of DOK family genes expression, immune characteristics, and drug sensitivity in human tumors.

ABSTRACT:

Introduction

DOK is a new type of regulatory protein family that participates in the regulation of tumor cell growth. However, most of the studies are conducted in cell lines, and systematic studies have not been conducted in human tumors.

Objectives

We conducted a comprehensive analysis of DOK based on its expression profile and its relationship with patient survival, immune infiltration, tumor microenvironment, and drug sensitivity.

Methods

We used the TCGA database to analyze the correlation between DOK family gene expression and prognosis and clinical stage. The protein expression of DOK in tumor tissues was analyzed by immunohistochemistry. Use the cBioPortal database to analyze the alteration frequency in DOK family genes in hu

SUBMITTER: Guan Y 

PROVIDER: S-EPMC8799871 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature