The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP <i>via</i> ER stress in pancreatic cancer cells.

ABSTRACT: Pancreatic adenocarcinoma (PAAD) is one of the most lethal malignancies. Although gemcitabine (GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C (Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect (80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-l-cysteine (NAC) reverse assay

SUBMITTER: Wang J 

PROVIDER: S-EPMC8800039 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature