A new blood-based RNA signature (R₉), for monitoring effectiveness of tuberculosis treatment in a South Indian longitudinal cohort.

ABSTRACT: Tuberculosis (TB) treatment involves a multidrug regimen for six months, and until two months, it is unclear if treatment is effective. This delay can lead to the evolution of drug resistance, lung damage, disease spread, and transmission. We identify a blood-based 9-gene signature using a computational pipeline that constructs and interrogates a genome-wide transcriptome-integrated protein-interaction network. The identified signature is able to determine treatment response at week 1-2 in three independent public datasets. Signature-based R₉-score correctly detected treatment response at individual timepoints (204 samples) from a newly developed South Indian longitudinal cohort involving 32 patients with pulmonary TB. These results are consistent with conventional clinical metr

SUBMITTER: Thakur C 

PROVIDER: S-EPMC8800112 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature