Mendelian randomization study of obesity and type 2 diabetes in hospitalized COVID-19 patients.

ABSTRACT:

Background

Both obesity and type 2 diabetes (T2D) are reported to be highly enriched in hospitalized COVID-19 patients. Due to the close correlation between obesity and T2D, it is important to examine whether obesity and T2D are independently related to COVID-19 hospitalization.

Objective

To examine the causal effect of obesity and T2D in hospitalized COVID-19 patients using Mendelian randomization (MR).

Research design and methods

This two-sample MR analysis applied genetic markers of obesity identified in the genome wide association study (GWAS) by the GIANT Consortium as instrumental variables (IVs) of obesity; and genetic markers of T2D identified by the DIAGRAM Consortium as IVs of T2D. The MR analysis was performed in hospitalized COVID-19 patient by the COVID-1

SUBMITTER: Qu HQ 

PROVIDER: S-EPMC8800123 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature