Safety of pre- or postoperative accelerated radiotherapy in 5 fractions: A randomized pilot trial.

ABSTRACT:

Objective

Neo-adjuvant radiotherapy (NART) for breast cancer has shown promising survival results in retrospective trials. However, there are some obstacles such as a chemotherapy delay, an increased overall treatment time (OTT) and the risk of increasing surgical morbidity. Accelerated radiotherapy (RT) in 5 fractions allows to deliver NART in a very short time span and minimizes the delay of surgery and chemotherapy. This trial investigates this NART schedule for safety, feasibility and OTT.

Material and methods

Twenty patients eligible for neo-adjuvant chemotherapy (NACT) and breast conserving surgery, were randomized between NART before NACT or NACT and postoperative RT. In both arms, RT treatment was given in 5 fractions to the whole breast with a simultaneously integra

SUBMITTER: Vakaet V 

PROVIDER: S-EPMC8800131 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature