Inflammatory monocytes and microglia play independent roles in inflammatory ictogenesis.

ABSTRACT:

Background

The pathogenic contribution of neuroinflammation to ictogenesis and epilepsy may provide a therapeutic target for reduction of seizure burden in patients that are currently underserved by traditional anti-seizure medications. The Theiler's murine encephalomyelitis virus (TMEV) model has provided important insights into the role of inflammation in ictogenesis, but questions remain regarding the relative contribution of microglia and inflammatory monocytes in this model.

Methods

Female C57BL/6 mice were inoculated by intracranial injection of 2 × 10⁵, 5 × 10⁴, 1.25 × 10⁴, or 3.125 × 10³ plaque-forming units (PFU) of the Daniel's strain of TMEV at 4-6 weeks of age. Infiltration of inflammatory monocytes, microglial activati

SUBMITTER: Howe CL 

PROVIDER: S-EPMC8800194 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature