Making sense of the linear genome, gene function and TADs.

ABSTRACT:

Background

Topologically associating domains (TADs) are thought to act as functional units in the genome. TADs co-localise genes and their regulatory elements as well as forming the unit of genome switching between active and inactive compartments. This has led to the speculation that genes which are required for similar processes may fall within the same TADs, allowing them to share regulatory programs and efficiently switch between chromatin compartments. However, evidence to link genes within TADs to the same regulatory program is limited.

Results

We investigated the functional similarity of genes which fall within the same TAD. To do this we developed a TAD randomisation algorithm to generate sets of "random TADs" to act as null distributions. We found that while pairs o

SUBMITTER: Long HS 

PROVIDER: S-EPMC8800309 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature