Saliva as a non-invasive specimen for COPD assessment.

ABSTRACT:

Background

People with COPD have been reported to bear a distinct airway microbiota from healthy individuals based on bronchoalveolar lavage (BAL) and sputum samples. Unfortunately, the collection of these samples involves relatively invasive procedures and is resource-demanding, limiting its regular use. Non-invasive samples from the upper airways could constitute an interesting alternative, but its relationship with COPD is still underexplored. We examined the merits of saliva to identify the typical profile of COPD oral bacteria and test its association with the disease.

Methods

Outpatients with COPD and age-sex matched healthy controls were recruited and characterised based on clinical parameters and 16S rRNA profiling of oral bacteria. A clustering analysis based on pat

SUBMITTER: Melo-Dias S 

PROVIDER: S-EPMC8800366 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature