Deep learning analysis of contrast-enhanced spectral mammography to determine histoprognostic factors of malignant breast tumours.

ABSTRACT:

Objective

To evaluate if a deep learning model can be used to characterise breast cancers on contrast-enhanced spectral mammography (CESM).

Methods

This retrospective mono-centric study included biopsy-proven invasive cancers with an enhancement on CESM. CESM images include low-energy images (LE) comparable to digital mammography and dual-energy subtracted images (DES) showing tumour angiogenesis. For each lesion, histologic type, tumour grade, estrogen receptor (ER) status, progesterone receptor (PR) status, HER-2 status, Ki-67 proliferation index, and the size of the invasive tumour were retrieved. The deep learning model used was a CheXNet-based model fine-tuned on CESM dataset. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was calcul

SUBMITTER: Dominique C 

PROVIDER: S-EPMC8800426 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature