Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single-cell sequencing.

ABSTRACT:

Background

Immune cells play important roles in mediating immune response and host defense against invading pathogens. However, insights into the molecular mechanisms governing circulating immune cell diversity among multiple species are limited.

Methods

In this study, we compared the single-cell transcriptomes of immune cells from 12 species. Distinct molecular profiles were characterized for different immune cell types, including T cells, B cells, natural killer cells, monocytes, and dendritic cells.

Results

Our data revealed the heterogeneity and compositions of circulating immune cells among 12 different species. Additionally, we explored the conserved and divergent cellular crosstalks and genetic regulatory networks among vertebrate immune cells. Notably, the lig

SUBMITTER: Li Z 

PROVIDER: S-EPMC8800483 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature