Tooth biomarkers to characterize the temporal dynamics of the fetal and early-life exposome.

ABSTRACT:

Background

Teeth have unique histology that make this biomatrix a time-capsule for retrospective exposure analysis of fetal and early life. However, most analytic methods require pulverizing the whole tooth, which eliminates exposure timing information. Further, the range of chemicals and endogenous exposures that can be measured in teeth has yet to be fully characterized.

Methods

We performed untargeted metabolomics on micro-dissected layers from naturally shed deciduous teeth. Using four liquid-chromatography high-resolution mass spectrometry analytical modes, we profiled small molecules (<1000 Da) from prenatal and postnatal tooth fractions. In addition, we employed linear regression on the tooth fraction pairs from 31 children to identify metabolites that discriminate be

SUBMITTER: Yu M 

PROVIDER: S-EPMC8800489 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature