[Proteolytic cleavage of neuroligins and functions of their cleavage products].

ABSTRACT: Neuroligin is a key protein that mediates synaptic development and maturation, and is closely related to neurodevelopmental diseases such as autism. In recent years, researchers have found that neuroligin can be hydrolyzed by various proteases at different stages of development, neuronal activities or pathological states of some neuropsychiatric diseases, thus affecting synaptic activity and participating in the occurrence and development of neurological diseases. The hydrolysates may have different physiological functions from the whole protein, and play different functions in neural activities, such as regulating synaptic plasticity, increasing synaptic strength and number, affecting amyloid-β polymerization, promoting glioma proliferation and growth, activating related signaling pathway

SUBMITTER: Yu J 

PROVIDER: S-EPMC8800723 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature