[Efficacy and safety of letrozole in treatment of male children with disorders of sex development].

ABSTRACT:

Objective

To investigate the efficacy and safety of aromatase inhibitor letrozole in treatment of male children with disorders of sex development (DSD).

Methods

Clinical data of 12 male DSD children with a mean age of 14.6±2.5 years admitted to Peking Union Medical College Hospital from January 2014 to January 2016 were retrospectively analyzed. The patients were treated with letrozole (1.25-2.5 mg, once a day) for 3 months or longer, and followed up for 0.5-2.5 years. Clinical manifestation and laboratory test findings were documented, and the efficacy and safety were evaluated.

Results

After half-year treatment, the blood luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone levels of patients increased (all P < 0.05), and estrogen

SUBMITTER: Yu B 

PROVIDER: S-EPMC8800807 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature