Overcoming Resistance to Kinase Inhibitors: The Paradigm of Chronic Myeloid Leukemia.

ABSTRACT: Protein kinases (PKs) play crucial roles in cellular proliferation and survival, hence their deregulation is a common event in the pathogenesis of solid and hematologic malignancies. Targeting PKs has been a promising strategy in cancer treatment, and there are now a variety of approved anticancer drugs targeting PKs. However, the phenomenon of resistance remains an obstacle to be addressed and overcoming resistance is a goal to be achieved. Chronic myeloid leukemia (CML) is the first as well as one of the best examples of a cancer that can be targeted by molecular therapy; hence, it can be used as a model disease for other cancers. This review aims to summarize up-to-date knowledge on the main mechanisms implicated in resistance to PK inhibitory therapies and to outline the main strategie

SUBMITTER: De Santis S 

PROVIDER: S-EPMC8800859 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature