EGFR transcriptionally upregulates UTX via STAT3 in non-small cell lung cancer.

ABSTRACT:

Background

Histone demethylase UTX has been reported to participate in the occurrence and development of many cancers in tissue-specific manners. However, the role of UTX in non-small cell lung cancer (NSCLC) and exactly what regulates the expression of UTX remains unclear. Here, we analyzed the role of UTX in NSCLC in association with the widely recognized tumor driver epidermal growth factor receptor (EGFR).

Methods

UTX levels in clinical samples were detected by immunohistochemistry staining, western blotting and real-time quantitative PCR. The expression of UTX in tumor tissue was correlated with the phosphorylation of EGFR. Cell proliferation and migration were evaluated by MTT and wound-healing assays. The impact of EGFR and its downstream pathways on UTX was explored

SUBMITTER: Zhou L 

PROVIDER: S-EPMC8800904 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature