Association of abdominal muscle area and density with glucose regulation: The multi-ethnic study of atherosclerosis (MESA).

ABSTRACT:

Aims

Previous characterisation of body composition as a type 2 diabetes mellitus (T2DM) risk factor has largely focused on adiposity, but less is known about the independent role of skeletal muscle. We examined associations between abdominal muscle and measures of glucose regulation.

Materials and methods

Cross-sectional analysis of 1,891 adults enrolled in the Multi-Ethnic Study of Atherosclerosis. Multivariable regression assessed associations between abdominal muscle area and density (measured by computed tomography) with fasting glucose, homeostasis model assessment of insulin resistance (HOMA-IR), and prevalent T2DM (fasting glucose ≥126 mg/dL or medication use).

Results

In minimally adjusted models (age, sex, race/ethnicity, income), a 1-SD increment in abdomina

SUBMITTER: Gold RS 

PROVIDER: S-EPMC8800952 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature