Identification and development of the novel 7-genes diagnostic signature by integrating multi cohorts based on osteoarthritis.

ABSTRACT:

Background

A chronic progressive degenerative joint disease, such as osteoarthritis (OA) is positively related to age. The medical economy is facing a major burden, because of the high disability rate seen in patients with OA. Therefore, to prevent and treat OA, exploring the diagnostic biomarkers of OA will be of great significance.

Methods

Differentially expressed genes (DEGs) were obtained from the Gene Expression Omnibus database using the RobustRankAggreg R package, and a protein-protein interaction network was constructed. The module was obtained from Cytoscape, and the four algorithms of degree, MNC, closeness, and MCC in CytoHubba were used to identify the hub genes. A diagnostic model was constructed using Support Vector Machines (SVM), and the ability of the model

SUBMITTER: Han Y 

PROVIDER: S-EPMC8801091 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature