Identification of four novel hub genes as monitoring biomarkers for colorectal cancer.

ABSTRACT:

Background

It must be admitted that the incidence of colorectal cancer (CRC) was on the rise all over the world, but the related treatment had not caught up. Further research on the underlying pathogenesis of CRC was conducive to improving the survival status of current CRC patients.

Methods

Differentially expressed genes (DEGs) screening were conducted based on "limma" and "RobustRankAggreg" package of R software. Weighted gene co-expression network analysis (WGCNA) was performed in the integrated DEGs that from The Cancer Genome Atlas (TCGA), and all samples of validation were from Gene Expression Omnlbus (GEO) dataset.

Results

The terms obtained in the functional annotation for primary DEGs indicated that they were associated with CRC. The MEyellow stand out whereb

SUBMITTER: Luo D 

PROVIDER: S-EPMC8801129 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature