Endotheliopathy is associated with slower liberation from mechanical ventilation: a cohort study.

ABSTRACT:

Background

Endotheliopathy is suggested as pivotal pathophysiology of sepsis and trauma-associated organ failure, but its role in acute respiratory failure is not yet determined. We investigated if endotheliopathy biomarkers at ICU admission are associated with illness severity and clinical outcomes in patients with acute respiratory failure requiring mechanical ventilation.

Methods

We conducted a prospective single-center cohort study including 459 mechanically ventilated adults at ICU admission. Plasma levels of three endotheliopathy biomarkers were measured at ICU admission: Syndecan-1, soluble Thrombomodulin (sTM), and Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1). The primary outcome was the rate of liberation from mechanical ventilation, which is presented to

SUBMITTER: Schonemann-Lund M 

PROVIDER: S-EPMC8801241 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature