Prediction of breast cancer risk based on flow variant analysis of circulating peripheral blood mononuclear cells.

ABSTRACT: Identifying women at high risk for developing breast cancer is potentially lifesaving. Patients with pathogenic genetic variants can embark on a program of surveillance for early detection, chemoprevention, and/or prophylactic surgery. Newly diagnosed cancer patients can also use the results of gene panel sequencing to make decisions about surgery; therefore, rapid turnaround time for results is critical. Cancer Risk B (CR-B), a test that uses flow variant assays to assess the effects of variants in the DNA double-strand break repair, was applied to two groups of subjects who underwent coincidental gene panel testing, thereby allowing an assessment of sensitivity, specificity and accuracy, and utility for annotating variants of uncertain significance (VUS). The test was compared in matched

SUBMITTER: Loke J 

PROVIDER: S-EPMC8801379 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature