Characterization of Leptin Receptor⁺ Stromal Cells in Lymph Node.

ABSTRACT: Lymph node (LN)-resident stromal cells play an essential role in the proper functioning of LNs. The stromal compartment of the LN undergoes significant compensatory changes to produce a milieu amenable for regulation of the immune response. We have identified a distinct population of leptin receptor-expressing (LepR⁺) stromal cells, located in the vicinity of the high endothelial venules (HEVs) and lymphatics. These LepR⁺ stromal cells expressed markers for fibroblastic reticular cells (FRCs), but they lacked markers for follicular dendritic cells (FDCs) and marginal reticular cells (MRCs). Leptin signaling deficiency led to heightened inflammatory responses within the LNs of db/db mice, leakiness of HEVs, and lymphatic fragmentation. Leptin signaling through the JAK/

SUBMITTER: Jiang L 

PROVIDER: S-EPMC8801441 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature