Influence of T Cell-Mediated Immune Surveillance on Somatic Mutation Occurrences in Melanoma.

ABSTRACT:

Background

Neoantigens are presented on the cancer cell surface by peptide-restricted human leukocyte antigen (HLA) proteins and can subsequently activate cognate T cells. It has been hypothesized that the observed somatic mutations in tumors are shaped by immunosurveillance.

Methods

We investigated all somatic mutations identified in The Cancer Genome Atlas (TCGA) Skin Cutaneous Melanoma (SKCM) samples. By applying a computational algorithm, we calculated the binding affinity of the resulting neo-peptides and their corresponding wild-type peptides with the major histocompatibility complex (MHC) Class I complex. We then examined the relationship between binding affinity alterations and mutation frequency.

Results

Our results show that neoantigens derived from recurren

SUBMITTER: Jiang C 

PROVIDER: S-EPMC8801458 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature