Systematic Characterization of the Group 2 House Dust Mite Allergen in Dermatophagoides microceras.

ABSTRACT:

Background

Allergic asthma, a chronic airway inflammatory disease, is a critical public health problem. Indoor house dust mites (HDMs) could cause allergic asthma. The prevalence of sensitization to Dermatophagoides microceras (Der m) was approximately 80% and is related to the immunoglobulin E crossing-reactivity of mites belonging to the same genus, Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farina (Der f). However, studies on Der m are scant.

Methods

We used integrated OMICs approaches to identify and characterize the group 2 mite allergen-like protein in Der m (Der m 2). We established a Der m 2-induced allergic asthma mouse model and treated the mice with a fungal immunomodulatory pro

SUBMITTER: Hu RH 

PROVIDER: S-EPMC8801679 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature