Antiviral metabolite 3'-deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19.

ABSTRACT:

Background

There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

Methods

Using untargeted high-resolution liquid chromatography coupled with mass spectrometry, we compared the admission serum metabolome of emergency department patients with viral infections (including COVID-19), bacterial infections, inflammatory conditions, and healthy controls. Sera from an independent cohort of emergency department patients admitted with viral or bacterial infections underwent profiling to validate findings. Associations between whole-blood gene expression and the identified metabolite of interest were examined.

Findings

3'-Deoxy-3',4'-didehydro-cytidine (ddhC), a free

SUBMITTER: Mehta R 

PROVIDER: S-EPMC8801973 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature