Aquaporin-9 facilitates liver regeneration following hepatectomy.

ABSTRACT: Aquaporin-9 (AQP9) is an aquaglyceroporin strongly expressed in the basolateral membrane of hepatocytes facing the sinusoids. AQP9 is permeable to hydrogen peroxide (H₂O₂) and glycerol as well as to water. Here, we report impaired liver regeneration in AQP9^-/- mice which involves altered steady-state H₂O₂ concentration and glucose metabolism in hepatocytes. AQP9^-/- mice showed remarkably delayed liver regeneration and increased mortality following 70% or 90% partial hepatectomy. Compared to AQP9^+/+ littermates, AQP9^-/- mice showed significantly greater hepatic H₂O₂ concentration and more severe liver injury. Fluorescence measurements indicated impaired H₂O₂ tr

SUBMITTER: Zhang B 

PROVIDER: S-EPMC8802049 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature