N-Glycosylation Patterns Correlate with Hepatocellular Carcinoma Genetic Subtypes.

ABSTRACT: Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths globally, and the incidence rate in the United States is increasing. Studies have identified inter- and intratumor heterogeneity as histologic and/or molecular subtypes/variants associated with response to certain molecular targeted therapies. Spatial HCC tissue profiling of N-linked glycosylation by matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS) may serve as a new method to evaluate the tumor heterogeneity. Previous work has identified significant changes in the N-linked glycosylation of HCC tumors but has not accounted for the heterogeneous genetic and molecular nature of HCC. To determine the correlation between HCC-specific N-glycosylation changes and genetic/molecular tumor f

SUBMITTER: DelaCourt A 

PROVIDER: S-EPMC8802325 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature