Lipid-related protein NECTIN2 is an important marker in the progression of carotid atherosclerosis: An intersection of clinical and basic studies.

ABSTRACT:

Background

The nectin cell adhesion molecule 2 (NECTIN2) protein is a cell adhesion molecule involved in lipid metabolism. We aimed to explore the potential role of NECTIN2 in carotid atherosclerosis (CA).

Materials and methods

Patients who underwent carotid endarterectomy (CEA) at the First Affiliated Hospital of Zhengzhou University were enrolled in this study. APOE^-/- rats fed western or normal diet were used to model early pathological changes in CA. The relationship between patients' lipid indices and plaque severity was assessed using ordinal regression analysis. Mendelian randomisation (MR) analysis was used to determine the causal links between low-density lipoprotein cholesterol (LDL-C) and atherosclerosis. After matching analysis of the single-cell trans

SUBMITTER: Li S 

PROVIDER: S-EPMC8802405 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature