Pre-treatment inflammatory parameters predict survival from endometrial cancer: A prospective database analysis.

ABSTRACT:

Purpose

Inflammation predisposes to tumorigenesis by damaging DNA, stimulating angiogenesis and potentiating pro-proliferative and anti-apoptotic processes. The aim of this study was to investigate whether pre-treatment biomarkers of systemic inflammation are associated with survival outcomes in endometrial cancer.

Patients and methods

Women with endometrial cancer were recruited to a prospective database study. Pre-treatment systemic markers of inflammation, including C-reactive protein (CRP), Glasgow Prognostic Score and lymphocyte-based ratios [neutrophil-lymphocyte ratio (NMR), monocyte-lymphocyte ratio (MLR), systemic immune-inflammation index (SII)], were analysed in relation to overall, endometrial cancer-specific and recurrence-free survival using Kaplan-Meier estima

SUBMITTER: Njoku K 

PROVIDER: S-EPMC8802781 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature