Primary central nervous system lymphoma in older adults and the rationale for maintenance strategies: a narrative review.

ABSTRACT:

Objective

To provide a summary and analysis of the evidence for various agents applied as maintenance therapy and highlight ongoing trials or trials in development that evaluate the efficacy of maintenance therapy strategies in older patients with primary central nervous system lymphoma (PCNSL).

Background

PCNSL are rare neoplasms that can have an aggressive course with short-lived remissions when compared to systemic diffuse large B-cell lymphoma (DLBCL). There is currently a paucity of evidence on treatment in older adults with PCNSL, who may be unfit to tolerate effective therapies for PCNSL. Those who can tolerate these therapies and survive PCNSL are at increased risk from developing treatment-related toxicity, functional decline, and debilitating neurotoxicity. While t

SUBMITTER: Tsang M 

PROVIDER: S-EPMC8802984 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature