Membrane protective role of autophagic machinery during infection of epithelial cells by Candida albicans.

ABSTRACT: Candida albicans (C. albicans) is an opportunistic pathogen causing infections ranging from superficial to life-threatening disseminated infections. In a susceptible host, C. albicans is able to translocate through the gut barrier, promoting its dissemination into deeper organs. C. albicans hyphae can invade human epithelial cells by two well-documented mechanisms: epithelial-driven endocytosis and C. albicans-driven active penetration. One mechanism by which host cells protect themselves against intracellular C. albicans is termed autophagy. The protective role of autophagy during C. albicans infection has been investigated in myeloid cells; however, far less is known regarding the role of this process during the infection of epithelial cel

SUBMITTER: Lapaquette P 

PROVIDER: S-EPMC8803057 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature