Coronary microcirculation damage in anthracycline cardiotoxicity.

ABSTRACT:

Aims

The aim of this study was to study changes in coronary microcirculation status during and after several cycles of anthracycline treatment.

Methods and results

Large-white male pigs (n=40) were included in different experimental protocols (ExPr.) according to anthracycline cumulative exposure [0.45 mg/kg intracoronary (IC) doxorubicin per injection] and follow-up: control (no doxorubicin); single injection and sacrifice either at 48 h (ExPr. 1) or 2 weeks (ExPr. 2); 3 injections 2 weeks apart (low cumulative dose) and sacrifice either 2 weeks (ExPr. 3) or 12 weeks (ExPr. 4) after third injection; five injections 2 weeks apart (high cumulative dose) and sacrifice 8 weeks after fifth injection (ExPr. 5). All groups were assessed by serial cardiac magnetic resonance (CMR) t

SUBMITTER: Galan-Arriola C 

PROVIDER: S-EPMC8803079 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature