Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer.

ABSTRACT:

Aims

After a myocardial infarction, the adult human heart lacks sufficient regenerative capacity to restore lost tissue, leading to heart failure progression. Finding novel ways to reprogram adult cardiomyocytes into a regenerative state is a major therapeutic goal. The epicardium, the outermost layer of the heart, contributes cardiovascular cell types to the forming heart and is a source of trophic signals to promote heart muscle growth during embryonic development. The epicardium is also essential for heart regeneration in zebrafish and neonatal mice and can be reactivated after injury in adult hearts to improve outcome. A recently identified mechanism of cell-cell communication and signalling is that mediated by extracellular vesicles (EVs). Here, we aimed to investigate epicard

SUBMITTER: Del Campo CV 

PROVIDER: S-EPMC8803084 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature