Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling.

ABSTRACT:

Aims

Pathological arterial remodelling including neointimal hyperplasia and atherosclerosis is the main underlying cause for occluding arterial diseases. Cezanne is a novel deubiquitinating enzyme, functioning as a NF-кB negative regulator, and plays a key role in renal inflammatory response and kidney injury induced by ischaemia. Here we attempted to examine its pathological role in vascular smooth muscle cell (VSMC) pathology and arterial remodelling.

Methods and results

Cezanne expression levels were consistently induced by various atherogenic stimuli in VSMCs, and in remodelled arteries upon injury. Functionally, VSMCs over-expressing wild-type Cezanne, but not the mutated catalytically-inactive Cezanne (C209S), had an increased proliferative ability and mobility, while

SUBMITTER: An W 

PROVIDER: S-EPMC8803089 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature