Multigene assessment of genetic risk for women for two or more breast cancers.

ABSTRACT:

Purpose

The prevalence, penetrance, and spectrum of pathogenic variants that predispose women to two or more breast cancers is largely unknown.

Methods

We queried clinical and genetic data from women with one or more breast cancer diagnosis who received multigene panel testing between 2013 and 2018. Clinical data were obtained from provider-completed test request forms. For each gene on the panel, a multivariable logistic regression model was constructed to test for association with risk of multiple breast cancer diagnoses. Models accounted for age of diagnosis, personal and family cancer history, and ancestry. Results are reported as odds ratios (ORs) with 95% confidence intervals (CIs).

Results

This study included 98,979 patients: 88,759 (89.7%) with a single breast

SUBMITTER: Weitzel JN 

PROVIDER: S-EPMC8803157 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature