Ceiling effect of clomiphene citrate on the testosterone to estradiol ratio in eugonadal infertile men.

ABSTRACT:

Introduction

The testosterone to estradiol ratio (T/E2 ratio) reportedly exerts a stronger effect on semen quality and sexual desire than does testosterone alone. Clomiphene citrate is a selective estrogen receptor modulator that has long been used as an empirical treatment option in the management of idiopathic oligozoospermia. Clomiphene may change the hypothalamus-pituitary-gonad axis and result in the alteration of the T/E2 ratio. No reliable data are available regarding the change in the T/E2 ratio after clomiphene use in eugonadism.

Methods

This study included 24 male patients who were diagnosed with idiopathic infertility with eugonadism. They all received clomiphene citrate (25 mg/day) as empirical treatment. Blood tests for serum testosterone, estradiol, prolactin,

SUBMITTER: Liao Y 

PROVIDER: S-EPMC8803167 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature