Evolution enhances mutational robustness and suppresses the emergence of a new phenotype: A new computational approach for studying evolution.

ABSTRACT: The aim of this paper is two-fold. First, we propose a new computational method to investigate the particularities of evolution. Second, we apply this method to a model of gene regulatory networks (GRNs) and explore the evolution of mutational robustness and bistability. Living systems have developed their functions through evolutionary processes. To understand the particularities of this process theoretically, evolutionary simulation (ES) alone is insufficient because the outcomes of ES depend on evolutionary pathways. We need a reference system for comparison. An appropriate reference system for this purpose is an ensemble of the randomly sampled genotypes. However, generating high-fitness genotypes by simple random sampling is difficult because such genotypes are rare. In this study, we

SUBMITTER: Kaneko T 

PROVIDER: S-EPMC8803174 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature