Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice.

ABSTRACT:

Purpose

Astronauts in space vehicles beyond low-Earth orbit will be exposed to high charge and energy (HZE) ions, and there is concern about potential adverse effects on the cardiovascular system. Thus far, most animal studies that assess cardiac effects of HZE particles have included only males. This study assessed the effects of oxygen ions (¹⁶O) as a representative ion of the intravehicular radiation environment on the heart of female mice.

Materials and methods

Female C57BL/6 J mice at 6 months of age were exposed to ¹⁶O (600 MeV/n) at 0.25-0.26 Gy/min to a total dose of 0, 0.1, or 0.25 Gy. Cardiac function and abdominal aorta blood velocity were measured with ultrasonography at 3, 5, 7, and 9 months after irradiation. At 2 weeks, 3 months, and 9 mo

SUBMITTER: Nemec-Bakk AS 

PROVIDER: S-EPMC8803400 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature