Kidney tubule health scores and their associations with incident CKD in women living with HIV.

ABSTRACT:

Objectives

Individual kidney tubule biomarkers are associated with chronic kidney disease (CKD) risk in people living with HIV (PLWH). Whether a combination of kidney biomarkers can be integrated into informative summary scores for PLWH is unknown.

Methods

We measured eight urine biomarkers of kidney tubule health at two visits over a 3-year period in 647 women living with HIV in the Women's Interagency Health Study. We integrated biomarkers into factor scores using exploratory factor analysis. We evaluated associations between CKD risk factors and factor scores, and used generalized estimating equations to determine associations between factor scores and risk of incident CKD.

Results

Factor analysis identified two unique factor scores: a tubule reabsorption score com

SUBMITTER: Ascher SB 

PROVIDER: S-EPMC8803539 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature