Identification of Inflammation-Related Biomarker Pro-ADM for Male Patients With Gout by Comprehensive Analysis.

ABSTRACT:

Objective

Gout is a local inflammatory disease caused by the deposition of monosodium urate (MSU) crystals in joints or adjacent tissues. When some gout occurs without hyperuricemia, or its clinical symptoms and signs are not typical, the diagnosis of gout will be delayed, so there is an urgent need to find a new biomarker to predict and diagnose of gout flare. Our research attempts to find the key genes and potential molecular mechanisms of gout through bioinformatics analysis, and collected general data and blood biochemical samples of patients with gout and healthy, then analyzed and compared the expression of factors regulated by key genes.

Method

GSE160170 were downloaded from GEO database for analysis. The data were normalized to identify the differentially expressed g

SUBMITTER: Qiu K 

PROVIDER: S-EPMC8803656 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature