FAP imaging in rare cancer entities-first clinical experience in a broad spectrum of malignancies.

ABSTRACT:

Purpose

⁶⁸ Ga-FAPI (fibroblast activation protein inhibitor) is a rapidly evolving and highly promising radiotracer for PET/CT imaging, presenting excellent results in a variety of tumor entities, particularly in epithelial carcinomas. This retrospective analysis sought to evaluate the potential and impact of FAPI-PET/CT in rare cancer diseases with respect to improvement in staging and therapy, based on tracer uptake in normal organs and tumors.

Material and methods

Fifty-five patients with rare tumor entities, defined by a prevalence of 1 person out of 2000 or less, received a ⁶⁸ Ga-FAPI-PET/CT scan. Fourteen women and 41 men (median age 60) were included within the following subgroups: cancer of unknown primary (n = 10), head and neck cancer (n = 13)

SUBMITTER: Dendl K 

PROVIDER: S-EPMC8803688 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature