Variation of Serum Uric Acid Is Associated With Gut Microbiota in Patients With Diabetes Mellitus.

ABSTRACT: Diabetes mellitus is a metabolic disease closely related to a disordered gut microbiome. Diabetic patients usually suffer from various metabolic disorders, such as increased serum uric acid levels. Although serum uric acid levels depend partially on intestine excretion, the relationship between uric acid and gut microbiome in diabetic patients remains unknown. We collected a total of 126 fecal samples from diabetic patients for 16S ribosomal RNA gene amplicon sequencing and recorded clinical data. We analyzed the correlation between clinical indicators and gut microbiota of diabetic patients using Spearman analysis. Since uric acid was the most prominent one, we classified diabetic patients based on their uric acid levels to find the microbiome associated with uric acid disturbance. We con

SUBMITTER: Zhang W 

PROVIDER: S-EPMC8803748 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature