Head-to-head comparison of [⁶⁸Ga]Ga-FAPI-04 and [¹⁸F]-FDG PET/CT in evaluating the extent of disease in gastric adenocarcinoma.

ABSTRACT:

Background

[¹⁸F]-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) may sometimes be suboptimal for imaging gastric adenocarcinoma. The recently introduced [⁶⁸Ga]Ga-FAPI-04 (FAPI) PET/CT targets tumor stroma and has shown considerable potential in evaluating the extent of disease in a variety of tumors.

Methods

We performed a head-to-head prospective comparison of FAPI and FDG PET/CT in the same group of 13 patients with gastric adenocarcinoma who presented for either initial staging (n = 10) or restaging (n = 3) of disease. Lesion detection and maximum standardized uptake value (SUV_max) were compared between the two types of radiotracers.

Results

All ten primary gastric tumors were FAPI-positive (100% d

SUBMITTER: Kuten J 

PROVIDER: S-EPMC8803763 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature