CXCR4 expression in glioblastoma tissue and the potential for PET imaging and treatment with [⁶⁸Ga]Ga-Pentixafor /[¹⁷⁷Lu]Lu-Pentixather.

ABSTRACT:

Purpose

CXCR4 (over)expression is found in multiple human cancer types, while expression is low or absent in healthy tissue. In glioblastoma it is associated with a poor prognosis and more extensive infiltrative phenotype. CXCR4 can be targeted by the diagnostic PET agent [⁶⁸Ga]Ga-Pentixafor and its therapeutic counterpart [¹⁷⁷Lu]Lu-Pentixather. We aimed to investigate the expression of CXCR4 in glioblastoma tissue to further examine the potential of these PET agents.

Methods

CXCR4 mRNA expression was examined using the R2 genomics platform. Glioblastoma tissue cores were stained for CXCR4. CXCR4 staining in tumor cells was scored. Stained tissue components (cytoplasm and/or nuclei of the tumor cells and blood vessels) were documented. Clinical characte

SUBMITTER: Jacobs SM 

PROVIDER: S-EPMC8803771 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature