The polymorphisms of extracellular matrix-remodeling genes are associated with pelvic organ prolapse.

ABSTRACT:

Introduction and hypothesis

Extracellular matrix (ECM) synthesis and metabolism abnormalities may influence the pelvic supporting system and lead to the occurrence and development of pelvic organ prolapse (POP). Genetic polymorphisms of such related genes have been increasingly studied. This study aims to explore the association between the single-nucleotide polymorphisms (SNPs) of genes encoding ECM processing enzymes (a disintegrin and metalloproteinase with thrombospondin motifs [ADAMTSs]), ECM degrading enzymes (matrix metalloproteinases [MMPs]) and their tissue inhibitors of metalloproteinase (TIMPs), and POP.

Methods

We conducted an association study including 48 women with POP at stages III and IV and 48 women without prolapse in Chinese groups. SNPs were identified u

SUBMITTER: Li L 

PROVIDER: S-EPMC8803794 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature