Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults.

ABSTRACT: Bacterial bloodstream infections are a major cause of morbidity and mortality among patients undergoing hematopoietic cell transplantation (HCT). Although previous research has demonstrated that pathogens may translocate from the gut microbiome into the bloodstream to cause infections, the mechanisms by which HCT patients acquire pathogens in their microbiome have not yet been described. Here, we use linked-read and short-read metagenomic sequencing to analyze 401 stool samples collected from 149 adults undergoing HCT and hospitalized in the same unit over three years, many of whom were roommates. We use metagenomic assembly and strain-specific comparison methods to search for high-identity bacterial strains, which may indicate transmission between the gut microbiomes of patients. Overall,

SUBMITTER: Siranosian BA 

PROVIDER: S-EPMC8803835 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature