Construction and validation of a pyroptosis-related gene signature associated with the tumor microenvironment in uveal melanoma.

ABSTRACT: The present study aimed to construct a pyroptosis-related gene signature in uveal melanoma (UM) patients. Patients from The Cancer Genome Atlas (TCGA) served as the training cohort, whereas patients (GSE22138) from Gene Expression Omnibus (GEO) served as the validation cohort. Using the Kaplan-Meier (KM) method, univariate analysis, and least absolute shrinkage and selection operator (LASSO) Cox regression, A five pyroptosis-related gene signature was constructed in the training cohort. Patients were divided into high- and low-risk groups. Survival analysis showed that patients in the high-risk group had a shorter survival time. Risk and survival analysis, time-independent receiver operating characteristic (ROC) curve analysis and principal component analysis (PCA) validated that the progn

SUBMITTER: Zhang F 

PROVIDER: S-EPMC8803850 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature