Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome.

ABSTRACT: Evidence highlights the comorbidity between emotional distress and irritable bowel syndrome (IBS) through the gut-brain axis. However, the underlying mechanism is largely unknown. Thus, the present study aimed to evaluate the associations among neurotransmitter levels and the gut microbiome profiles in persons with IBS and emotional distress. In this nested case-controlled study, emotional symptoms, including anxiety and depressive symptoms, were evaluated in 40 persons with IBS and 20 healthy controls (HC). Plasma neurotransmitters levels (serotonin and norepinephrine) and the gut microbiome profile of the collected fecal samples were examined. Emotional distress and microbiome profile were significantly different between IBS and HC groups. Lower but not significant neurotransmitters' lev

SUBMITTER: Barandouzi ZA 

PROVIDER: S-EPMC8803858 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature