An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection.

ABSTRACT: The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades. Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an inflammatory "cytokine storm" (CS) plays a determinant role. Here, we used transcriptomic data from the bronchoalveolar lavage fluid (BALF) of COVID-19 patients undergoing a CS to obtain gene-signatures associated to this pathology. Using these signatures, we interrogated the Connectivity Map (CMap) dataset that contains the effects of over 5000 small molecules on the transcriptome of human cell lines, and looked for molecules which effects on transcription mimic or oppose those of the CS. As expected, molecules that potentiate immune responses such as PKC activators are predicted to worsen the CS. In addition, we id

SUBMITTER: Sanchez-Burgos L 

PROVIDER: S-EPMC8803893 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature